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In vivo inhibition of HTT expression by ss-siRNA ISIS 594246 in Hdh Q175/Q7 model mice. (A) Western blot images of different brain tissues form HdhQ175/Q7 mice after treating with 300 μg ss-siRNA 594246 or phosphate buffered saline (n = 4). (B) Quantification of HTT protein levels from (A). Error bars represent standard error of the mean. *p < 0.05; **p < 0.01; ***p < 0.001.
