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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Adv Healthc Mater. 2013 Nov 19;3(6):811–816. doi: 10.1002/adhm.201300490

Figure 1. Schematic of the focused ultrasound (FUS)-mediated insulin delivery using nano-network.

Figure 1

a) Nanoparticles (NPs) encapsulating insulin are made of PLGA and coated with chitosan and alginate, respectively. b) Nano-network (NN) is obtained by mixing oppositely charged nanoparticles together. The FUS triggers the dissociation of NN and promotes insulin release from the formulation. c) Schematic envision of noninvasive based long-term drug delivery triggered by the FUS after a subcutaneously injection of NN.