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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Curr Breast Cancer Rep. 2014 Feb 13;6(2):71–78. doi: 10.1007/s12609-014-0140-5

Figure 1. Preclinical insights of AR signaling according to breast cancer subtype.

Figure 1

AR antagonists have been shown to inhibit cell proliferation in A) TNBC AR+ and B) ER-HER2+AR+ breast cancer subtypes, the latter through its interaction with the HER2/3, Wnt/β-Catenin and c-MYC pathways. On the other hand, AR antagonists results in increased cell proliferation in C) ER+AR+ breast cancer cells through its interaction with the ER signaling pathway, and AR agonists may therefore be of benefit in this setting. D) AR overexpression may be a mechanism of Tamoxifen resistance, and inhibition of AR may be of benefit in this setting.