. 2014 Jun 10;20(17):2873–2889. doi: 10.1089/ars.2013.5603

Table 1.

Characteristics of the NADPH Oxidase Family

Enzyme	Interaction partner(s)^a	Cellular localization	Major tissue distribution^b
NOX1	p22^phox, NOXA1/p67^phox NOXO1/p47phox, Rac, Tks4/5, PDI (ERp72), Hsp90	Plasma membrane caveoli, lipid rafts	Colon epithelium
NOX2	p22^phox, p67^phox, p47^phox, Rac, p40phox, Hsp90	Plasma membrane	Phagocytes
NOX3	p22^phox, NOXA1/p67^phox, NOXO1/p47phox, Rac	Plasma membrane	Inner ear
NOX4	p22^phox, Poldip2, Tks4/5, PDI	Plasma membrane, ER, mitochondrial and nuclear membranes	Kidney, ovary, brain
NOX5	Hsp90, c-Abl	Plasma membrane, ER, nuclear membrane	Spleen, testis, lymph node
DUOX1	DUOXA1, TPO, EFP1, NOXA1	Plasma membrane	Thyroid, lung, prostate, testis
DUOX2	DUOXA2, TPO, EFP1, NOXA1	Plasma membrane, ER, vesicles	Thyroid, salivary gland, colon, pancreas

^{^a}

Interaction partners nonessential for activity are in italics.

^{^b}

Literature references for tissue distribution assignments: (5, 8, 9, 20, 28, 68, 127).

DUOX, dual oxidase; Tks, tyrosine kinase substrate.