Table 1.
Transformeda YQOL-R Perceptual Scores and Change from Baselineb Scores Stratified by Participant-Perceived QOL at Baseline or by Study Completion Status
| Stratified by participant-perceived QOL at baseline | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Poorc QOL (n=32) | Othersd (n=232) | ||||||||
| Observed value | Change from baselineb score | Observed value | Change from baselineb score | ||||||
| Variables | Visit | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) |
| Transformeda YQOL-R total perceptual score | Baselineb | 32 | 57.6 (9.84) | - | - | 232 | 82.8 (7.38) | - | - |
| Week 28 | 20 | 75.2 (10.63) | 20 | 17.6 (9.51) | 160 | 85.9 (8.49) | 160 | 3.0 (7.93) | |
| Week 52 | 17 | 70.9 (14.24) | 17 | 14.7 (11.16) | 136 | 86.7 (7.89) | 136 | 3.8 (8.59) | |
| Week 52/ET | 26 | 70.0 (15.29) | 26 | 12.5 (13.02) | 211 | 85.6 (9.03) | 211 | 2.9 (8.72) | |
| Transformeda YQOL-R domain scores | |||||||||
| Self | Baselineb | 32 | 53.6 (10.96) | - | - | 232 | 70.4 (9.05) | - | - |
| Week 52/ET | 26 | 63.7 (11.77) | 26 | 9.8 (13.55) | 211 | 75.5 (8.72) | 211 | 5.1 (9.83) | |
| Relationships | Baselineb | 32 | 58.0 (16.11) | - | - | 232 | 84.2 (9.89) | - | - |
| Week 52/ET | 26 | 69.0 (17.73) | 26 | 11.4 (16.43) | 211 | 86.8 (11.16) | 211 | 2.7 (10.83) | |
| Environment | Baselineb | 32 | 62.2 (14.15) | - | - | 232 | 85.5 (9.44) | - | - |
| Week 52/ET | 26 | 72.8 (16.62) | 26 | 11.4 (12.63) | 211 | 88.9 (10.33) | 211 | 3.3 (10.09) | |
| General | Baselineb | 32 | 56.6 (17.79) | - | - | 232 | 91.3 (10.10) | - | - |
| Week 52/ET | 26 | 74.4 (22.45) | 26 | 17.6 (22.26) | 211 | 91.4 (11.73) | 211 | 0.4 (13.48) | |
| Stratified by completerse vs. noncompletersf of current study | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Study completerse (n=156) | Study noncompletersf (n=109) | ||||||||
| Observed value | Change from baselineb score | Observed value | Change from baselineb score | ||||||
| Variables | Visit | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) | n | Mean (SD) |
| Transformeda YQOL-R Total Perceptual Score | Baselineb | 155 | 79.9 (11.66) | - | - | 109 | 79.6 (10.76) | - | - |
| Week 52/ET | 154 | 84.9 (10.04) | 153 | 5.0 (9.52)g | 82 | 82.1 (12.55) | 82 | 1.9 (9.64) | |
| Transformeda YQOL-R domain scores | |||||||||
| Self | Baselineb | 155 | 68.4 (11.24) | - | - | 109 | 68.3 (10.12) | - | - |
| Week 52/ET | 154 | 74.6 (9.45) | 153 | 6.2 (10.38)g | 82 | 73.6 (10.32) | 82 | 4.9 (10.18) | |
| Relationships | Baselineb | 155 | 81.1 (14.45) | - | - | 109 | 80.9 (12.79) | - | - |
| Week 52/ET | 154 | 85.8 (12.59) | 153 | 4.7 (11.58)g | 82 | 83.0 (14.27) | 82 | 1.8 (12.03) | |
| Environment | Baselineb | 155 | 83.3 (12.93) | - | - | 109 | 81.8 (12.22) | - | - |
| Week 52/ET | 154 | 88.4 (11.03) | 153 | 5.1 (10.42)g | 82 | 84.9 (14.02) | 82 | 2.4 (10.86) | |
| General | Baselineb | 155 | 86.8 (16.06) | - | - | 109 | 87.5 (15.95) | - | - |
| Week 52/ET | 154 | 90.9 (12.00) | 153 | 4.0 (14.47)g | 82 | 86.9 (17.65) | 82 | –1.4 (16.64) | |
a
The YQOL-R raw score is transformed to a 0–100 point scale to assist in result interpretation; higher scores indicate improvement in QOL.
b
Baseline is based on the baseline of the antecedent 4 week study.
c
Poor=participants with YQOL-R scores ≤(mean−1 SD).
d
Others=participants with YQOL-R scores >(mean−1 SD).
e
Study completers=participants who completed the current study.
f
Study noncompleters=participants who did not complete the current study.
g
p≤0.001 based on a two sided one sample t test.
ET, early termination; QOL, quality of life; YQOL-R, Youth Quality of Life-Research Version.