Table 3.

Anti-inflammatory effect of 20 mg/kg and 40 mg/kg intraperitoneal injections of compounds 6a, 6c, 6f, 9b, 10b, 11, 12c, 13, and 14, and indomethacin 5 mg/kg against carrageenan-induced paw edema in rats

Compound number	Mean percent reduction in paw edema from control valuea
	20 mg/kg	40 mg/kg
Controlb	−0.70±0.03d
6a	13.16±4.42c	14.05±5.21c
6c	22.50±5.25c	14.05±5.21c
6f	33.52±0.23d	38.89±0.14d
9b	−1.42±5.21 c	2.06±6.01c
10b	17.32±3.21d	29.54±2.08d
11	2.53±5.21c	2.46±6.01c
12b	17.41±1.11d	26.96±1.91d
13	44.62±0.11d	62.19±0.14d
14	28.86±0.09d	58.62±0.07d
Indomethacin 5 mg/kg	52.79±0.04d

Notes:

^aResults are expressed as the mean percent inhibition ± standard error of the mean (n=5) and compared using the Student’s t-test;

^bgroup injected with 1 mL of 0.5% aqueous carboxymethyl cellulose solution;

^csignificant difference at P<0.05;

^dsignificant difference at P<0.005.