Table 1.

Comparison of genotype and allele frequencies of MTHFR C677T, MTHFR A1298C, SLC19A1 G80A, SLC19A1 C696T, MTRR A66G polymorphisms between REPL patients and control subjects

Genotype and allele	Control (n = 166)	Case (n = 82)	AOR (95 % CI)	P value
MTHFR C677T
CC	53 (0.319)	29 (0.354)	1.0 (ref)	–
CT	83 (0.500)	43 (0.524)	0.92 (0.51–1.68)	0.794
TT	30 (0.181)	10 (0.122)	0.56 (0.23–1.33)	0.185
CT+TT			0.82 (0.47–1.46)	0.507
C	189 (0.569)	101 (0.616)	1.0 (ref)	–
T	143 (0.431)	63 (0.384)	0.79 (0.54–1.17)	0.246
MTHFR A1298C
AA	132 (0.795)	49 (0.598)	1.0 (ref)	–
AC	31 (0.187)	31 (0.378)	2.58 (1.40–4.74)#	0.002
CC	3 (0.018)	2 (0.024)	2.00 (0.32–12.47)	0.459
AC+CC			2.53 (1.40–4.57)	0.002
A	295 (0.889)	129 (0.787)	1.0 (ref)	–
C	37 (0.111)	35 (0.213)	2.13 (1.27–3.57)	0.004
SLC19A1 G80A
GG	45 (0.271)	22 (0.268)	1.0 (ref)	–
GA	94 (0.566)	37 (0.451)	0.86 (0.45–1.64)	0.643
AA	27 (0.163)	23 (0.281)	1.84 (0.85–3.98)	0.122
GA+AA			1.08 (0.59–1.99)	0.807
G	184 (0.554)	81 (0.494)	1.0 (ref)	–
A	148 (0.446)	83 (0.506)	1.31 (0.89–1.93)	0.165
SLC19A1 C696T
CC	45 (0.271)	23 (0.280)	1.0 (ref)	–
CT	94 (0.566)	35 (0.427)	0.76 (0.40–1.46)	0.411
TT	27 (0.163)	24 (0.293)	1.86 (0.87–3.99)	0.110
CT+TT			1.00 (0.55–1.84)	0.988
C	184 (0.554)	81 (0.494)	1.0 (ref)	–
T	148 (0.446)	83 (0.506)	1.32 (0.90–1.93)	0.158
MTRR A66G
AA	98 (0.590)	43 (0.524)	1.0 (ref)	–
AG	53 (0.319)	28 (0.341)	1.12 (0.62–2.04)	0.701
GG	15 (0.090)	11 (0.134)	1.69 (0.71–4.06)	0.239
AG+GG			1.25 (0.72–2.15)	0.429
A	249 (0.750)	114 (0.695)	1.0 (ref)	–
G	83 (0.250)	50 (0.305)	1.29 (0.84–1.97)	0.241

Ref is the reference group (same as the follows)

AOR is adjusted odd ratio by body mass index of female participants

^#Significance level α = 0.0167 by Bonferroni correction