Table 1.
Pathways with the highest number of genes carrying rare variants with a high-to-moderate predicted biological effect ranked by Panther
| Pathway | Genes | |
|---|---|---|
| 1 | Wnt signaling | 32 |
| 2 | Inflammation mediated by chemokine and cytokine signaling | 26 |
| 3 | Integrin signaling pathway | 21 |
| 4 | Cadherin signaling pathway | 19 |
| 5 | Gonadotropin releasing hormone receptor | 17 |
| 6 | Nicotinic acetylcholine receptor signaling | 14 |
| 7 | PDGF signaling | 13 |
| 8 | Angiogenesis | 13 |
| 9 | Cytoskeletal regulation by Rho GTPase | 12 |
| 10 | Huntington disease | 12 |