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. 2014 May 19;9(5):e97835. doi: 10.1371/journal.pone.0097835

Figure 3. The mechanical properties of functionalized cellulose 3D scaffolds and C2C12 myoblast cultured within the 3D cellulose scaffolds.

Figure 3

A) The local mechanical elasticity of native tissue, decellularized (SDS), collagen functionalized (SDS+Coll) and glutaraldehyde (SDS+GA) cross-linked cellulose scaffolds. The native tissue and unmodified scaffolds do not display any significant difference in mechanical properties. Both the collagen functionalized and chemically cross-linked scaffolds displayed a significant increase in elasticity compared to the DMEM scaffolds (*** = p<0.001). The (B) decellularized (SDS), (C) Collagen functionalized (SDS+Coll) and (D) glutaraldheyde cross-linked (SDS+GA) scaffolds all support the growth of C2C12 cells. Phase contrast images of C2C12 cells after two weeks of growth reveal the presence of cell colonies. Scale bar = 200 µm.