. 2014 May 19;9(5):e97616. doi: 10.1371/journal.pone.0097616

Table 2. Results of overall and stratified analyses for the associations of ERCC1 polymorphisms and risk of lung cancer^**.

Variables	No. of	Sample size	Homozygous			Heterozygous			Dominant			Recessive
	studies	Case/control	OR (95% CI)	P^het	I² (%)	OR (95% CI)	P^het	I² (%)	OR (95% CI)	P^het	I² (%)	OR (95% CI)	P^het	I² (%)
rs11615 T>C ^**
Total	10	7779/10655	1.08 (0.98–1.19)	0.338	11.3	1.02 (0.95–1.09)	0.391	5.4	1.03 (0.96–1.10)	0.379	6.8	1.05 (0.97–1.13)	0.361	8.8
Ethnicities
Asian	5	2236/2235	1.24 (0.97–1.58)	0.151	40.5	1.23 (0.96–1.58)	0295	18.9	1.24 (0.98–1.57)	0.191	34.6	1.05 (0.93–1.18)	0.179	36.3
Caucasian	5	5543/8420	1.05 (0.95–1.17)	0.723	0.0	1.00 (0.93–1.08)	0.697	0.0	1.01 (0.94–1.09)	0.883	0.0	1.05 (0.95–1.16)	0.465	0.0
Source of control
HB	4	3612/5162	1.08 (0.94–1.24)	0.107	50.7	1.05 (0.95–1.16)	0.108	50.6	1.05 (0.95–1.15)	0.09	53.6	1.02 (0.91–1.14)	0.326	13.3
PB	6	4167/5493	1.09 (0.95–1.25)	0.543	0.0	0.99 (0.89–1.09)	0.726	0.0	1.01 (0.92–1.12)	0.70	0.0	1.08 (0.97–1.20)	0.319	14.8
Smoking status
Smokers	3	657/468	2.16 (1.41–3.30)	0.099	56.8	1.77 (1.21–2.60)	0.462	0.0	1.94 (1.36–2.79)	0.234	31.2	1.32 (0.83–2.09)	0.042	68.6
Non-smokers	3	494/616	2.39 (1.47–3.88)	0.542	0.0	2.39 (1.44–3.95)	0.237	30.5	2.40 (1.49–3.85)	0.399	0.0	1.19 (0.94–1.52)	0.628	0.0
rs3212986 C>A
Total	6	6639/8630	1.00 (0.88–1.14)	0.609	0.0	0.97 (0.91–1.04)	0.737	0.0	0.97 (0.91–1.04)	0.784	0.0	1.01 (0.89–1.15)	0.558	0.0
Ethnicities
Asian	2	1188/1186	1.05 (0.80–1.37)	0.905	0.0	1.00 (0.84–1.20)	0.950	0.0	1.01 (0.86–1.20)	0.939	0.0	1.05 (0.83–1.33)	0.846	0.0
Caucasian	4	5451/7444	0.98 (0.85–1.14)	0.330	12.6	0.96 (0.89–1.04)	0.463	0.0	0.97 (0.90–1.04)	0.539	0.0	1.00 (0.86–1.15)	0.287	20.4
Source of control
HB	2	2836/4428	1.00 (0.82–1.21)	0.770	0.0	0.91 (0.83–1.01)	0.777	0.0	0.93 (0.84–1.02)	0.662	0.0	1.04 (0.86–1.24)	0794	0.0
PB	4	3803/4202	1.00 (.83–1.19)	0.319	14.6	1.02 (0.93–1.12)	0.969	0.0	1.02 (0.93–1.11)	0.949	0.0	0.99 (0.83–1.18)	0.288	20.2
rs3212961 A>C
Total	4	1770/1830	0.87 (0.71–1.07)	0.318	14.8	0.92 (0.77–1.11)	0.216	32.7	0.90 (0.76–1.07)	0.167	40.8	0.91 (0.79–1.06)	0.855	0.0
Ethnicities
Asian	3	1436/1428	0.87 (0.71–1.08)	0.177	42.3	0.92 (0.76–1.11)	0.108	55.1	0.91 (0.76–1.08)	0.082	60.1	0.93 (0.79–1.09)	0.749	0.0
Caucasian	1	334/402	0.79(0.36–1.74)			0.92 (0.40–2.10)			0.82 (0.38–1.80)			0.85 (0.61–1.19)
rs3212948 G>C
Total	3	1537/1835	0.84 (0.65–1.08)	0.643	0.0	0.78 (0.67–0.90)	0.321	12.0	0.79 (0.69–0.90)	0.287	19.9	0.93 (0.73–1.19)	0.782	0.0
rs2298881 C>A
Total	4	4653/6921	1.11 (0.91–1.36)	0.938	0.0	1.03 (0.94–1.13)	0.530	0.0	1.04 (0.95–1.13)	0.530	0.0	1.10 (0.91–1.32)	0.964	0.0
Ethnicities
Asian	2	1317/1329	1.13 (0.90–1.43)	0.562	0.0	1.04 (0.88–1.22)	0.732	0.0	1.06 (0.90–1.24)	0.623	0.0	1.11 (0.90–1.37)	0.634	0.0
Caucasian	2	3336/5592	1.06 (0.73–1.56)	0.992	0.0	1.03 (0.92–1.15)	0.148	52.1	1.03 (0.93–1.14)	0.168	47.3	1.06 (0.72–1.55)	0.926	0.0

CI, confidence interval; OR, odds ratio. The results were in bold, if the 95% CI excluded 1 or P<0.05.

P ^het value of Q-test for heterogeneity test; random-effects model was used when P<0.05 for heterogeneity test; otherwise, fixed-effects model was used. Significant results are listed in bold.

**Study by Zienolddiny et al. was excluded for rs11615 analysis.

Table 2. Results of overall and stratified analyses for the associations of ERCC1 polymorphisms and risk of lung cancer**.

Table 2. Results of overall and stratified analyses for the associations of ERCC1 polymorphisms and risk of lung cancer^**.