Table 4.
Nested Linear Regression Models of the Association Between Mental Health Conditions and Percent Time in Therapeutic Range, a Measure of Anticoagulation Control (N = 103,897)
| Model 1 | Model 2 | Model 3 | Model 4 | |
|---|---|---|---|---|
| Intercept | 63.06† | 64.22† | 66.35† | 67.54† |
| Model R2 | 0.0168 | 0.0306 | 0.0532 | 0.0756 |
| Anxiety disorders | −1.31† | −1.18† | −0.86† | 0.18 |
| Bipolar disorder | −5.50† | −4.55† | −3.74† | −2.63† |
| Depression | −5.06† | −4.41† | −3.54† | −2.26† |
| PTSD | −2.22† | −1.12† | −0.68* | −0.01 |
| Schizophrenia | −4.40† | −2.22† | −1.43* | −0.36 |
| Other psychotic disorders | −5.59† | −5.77† | −4.51† | −2.92† |
*p < 0.05 and †p < 0.001
The coefficients associated with the other covariates are included in the Online Appendix 7
Model 1 adjusts for no other covariates
Model 2 adjusts for demographic information (gender, age, and race)
Model 3 adjusts for demographic information and comorbid conditions (hypertension, stroke, chronic liver disease, chronic kidney disease, alcohol abuse, and non-alcohol substance abuse)
Model 4 adjusts for demographic information, comorbid conditions, date of warfarin inception, indication for warfarin therapy, and the number of non-warfarin medications and hospitalizations