Table 5.

Hazard Ratios Based on Cox Regression Models to Predict Episodes of Major Hemorrhage

	All patients (N = 86,492‡)		Only patients with MHCs (N = 24,439§)
	Model 1	Model 2	Model 3: without imputation	Model 4: with imputation
Any mental health condition	1.19 (1.11–1.27)†	–	–	–
GAF >50‖	–	–	0.86 (0.73–1.02)	1.00 (0.90–1.12)
GAF missing‖			1.01 (0.87–1.18)
Psychiatric hospitalization	–	–	1.10 (0.86–1.41)	1.12 (0.88–1.43)
Anxiety disorders	–	1.13 (1.02–1.26)*	1.12 (0.99–1.27)	1.10 (0.98–1.25)
Bipolar disorder	–	1.10 (0.91–1.34)	1.11 (0.91–1.36)	1.09 (0.89–1.33)
Depression	–	1.16 (1.07–1.25)†	1.14 (0.99–1.30)	1.12 (0.98–1.27)
PTSD	–	1.01 (0.89–1.14)	1.00 (0.87–1.15)	0.98 (0.86–1.13)
Schizophrenia	–	0.84 (0.61–1.16)	0.82 (0.59–1.15)	0.81 (0.59–1.13)
Other psychotic disorders	–	1.25 (1.05–1.49)*	1.24 (1.02–1.50)*	1.24 (1.02–1.50)*

GAF: Global Assessment of Functioning score; MHC: mental health condition

PTSD: Post-traumatic stress disorder; TTR: percent time in therapeutic range

*p < 0.05 and †p < 0.001

Covariates for all models include age, TTR, hypertension, stroke, chronic liver disease, chronic kidney disease, alcohol abuse, and non-alcohol substance abuse. Online Appendix 4 includes the coefficients for all of the covariates not shown here

‡Excluded 17,405 patients with Medicare Part C without major hemorrhage data

§Excluded 3,777 patients with Medicare Part C without major hemorrhage data

‖Compared to reference group GAF ≤ 50