Figure 1.

Schematic of the steps involved in research prioritization (adapted from the PCORI Methodology Report).²⁸ The proposed methodology begins with a systematic and inclusive process for topic generation. The systematic engagement of multiple stakeholders, especially patients, is a critical component of topic generation. This is followed by a multistep prioritization beginning with systematic reviews and gap analysis to identify what is known, and what desirable knowledge is not known. The VOI analysis is a methodology used to identify the research questions with the greatest potential to improve population health. Finally, proposals addressing the high value research questions are subjected to peer and stakeholder review to ensure methodological rigor. Although these steps are depicted as linear, in practice, prioritization and reprioritization occur at all stages of the process. The integration of patient viewpoints is included at all stages of research prioritization.