Box 1: Attributes of Patient-Centered Outcomes Research (PCOR) (http://www.pcori.org/what-we-do/pcor/)

1. Assesses the benefits and harms of preventive, diagnostic, therapeutic, palliative, or health delivery system interventions to inform decision making, highlighting comparisons and outcomes that matter to people;

2. Is inclusive of an individual’s preferences, autonomy and needs, focusing on outcomes that people notice and care about such as survival, function, symptoms, and health related quality of life;

3. Incorporates a wide variety of settings and diversity of participants to address individual differences and barriers to implementation and dissemination; and

4. Investigates (or may investigate) optimizing outcomes while addressing burden to individuals, availability of services, technology, and personnel, and other stakeholder perspectives.