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. 2014 Apr 7;32(15):1620–1629. doi: 10.1200/JCO.2013.53.0204

Table 4.

Starting Doses and Prespecified Dose Adjustments in the Axis Trial

Drug Second Dose Reduction
First Dose Reduction
Starting Dose
First Dose Escalation
Second Dose Escalation
Dose (mg) Schedule % Starting Dose Dose (mg) Schedule % Starting Dose Dose (mg) Schedule Dose (mg) Schedule % Starting Dose Dose (mg) Schedule % Starting Dose
Axitinib 2 Twice a day 40 3 Twice a day 60 5 Twice a day 7 Twice a day 140 10 Twice a day 200
Sorafenib 400 Once every other day 25 400 Once a day 50 400 Twice a day None allowed None allowed