Table 4.
Starting Doses and Prespecified Dose Adjustments in the Axis Trial
| Drug | Second Dose Reduction |
First Dose Reduction |
Starting Dose |
First Dose Escalation |
Second Dose Escalation |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dose (mg) | Schedule | % Starting Dose | Dose (mg) | Schedule | % Starting Dose | Dose (mg) | Schedule | Dose (mg) | Schedule | % Starting Dose | Dose (mg) | Schedule | % Starting Dose | |
| Axitinib | 2 | Twice a day | 40 | 3 | Twice a day | 60 | 5 | Twice a day | 7 | Twice a day | 140 | 10 | Twice a day | 200 |
| Sorafenib | 400 | Once every other day | 25 | 400 | Once a day | 50 | 400 | Twice a day | None allowed | None allowed | ||||