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. 2014 Apr 28;48(2):108–116. doi: 10.4132/KoreanJPathol.2014.48.2.108

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© 2014 The Korean Society of Pathologists/The Korean Society for Cytopathology

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1 — Insulin-like growth factor II mRNA-binding protein 3 (IMP3), Ki-67, and p53 expression levels in a clear cell renal cell carcinoma (CCRCC) patient with metastasis. (A) Histologic features of CCRCC with metastasis (hematoxylin and eosin staining). (B) Immunohistochemical staining for IMP3 shows diffuse positivity in cytoplasmic and membranous pattern. (C) Ki-67 proliferating index is high (greater than 10%). (D) Immunohistochemical staining for p53 shows positivity in more than 5% of tumor cells.