Table 5.
Significantly up-regulated ( p < 0.05; FC > 2) detoxification genes in whole genome microarray comparison of Wad Medani resistant vs . Dongola colony
| Gene | Vectorbase descriptor | FC min | FC max | N° probes |
|---|---|---|---|---|
|
Cytochrome P450s |
|
|
|
|
|
CYP6Z3 |
AGAP008217-RA |
7.97 |
13.45 |
4 |
|
CYP6P3 |
AGAP002865-RA |
6.73 |
14.99 |
4 |
|
CYP6M2 |
AGAP008212-RA |
4.82 |
5.03 |
4 |
|
CYP4H24 |
AGAP013490-RA |
4.50 |
|
1 |
|
CYP6P4 |
AGAP002867-RA |
3.93 |
4.36 |
4 |
|
CYP6Z2 |
AGAP008218-RA |
3.57 |
4.38 |
3 |
|
CYP6AG1 |
AGAP013511-RA |
3.08 |
3.14 |
2 |
|
CYP6M3 |
AGAP008213-RA |
2.80 |
2.82 |
3 |
|
CYP302A1 |
AGAP005992-RA |
2.73 |
|
1 |
|
CYP9J5 |
AGAP012296-RA |
2.67 |
2.71 |
4 |
|
CYP9K1 |
AGAP000818-RA |
2.37 |
|
1 |
|
CYP4H19 |
AGAP000088-RA |
2.32 |
4.37 |
4 |
|
CYP9L2 |
AGAP012850-RA |
2.10 |
|
1 |
|
CYP4C28 |
AGAP010414-RA |
2.05 |
2.97 |
4 |
|
CYP12F2 |
AGAP008021-RA |
2.00 |
2.42 |
4 |
|
CYP6AK1 |
AGAP010961-RA |
2.03 |
|
1 |
|
CYP325J1 |
AGAP001443-RA |
3.72 |
3.81 |
3 |
|
Carboxylesterases |
|
|
|
|
| carboxylesterase |
AGAP010912-RA |
6.94 |
|
1 |
|
COEglt2H |
AGAP010914-RA |
6.68 |
|
1 |
|
COEJHE2E |
AGAP005834-RA |
3.06 |
4.01 |
3 |
|
COEJHE5E |
AGAP005837-RA |
4.65 |
10.22 |
2 |
|
COEAE2D |
AGAP005757-RA |
2.01 |
2.07 |
3 |
|
COE09941 - Putative Carboxylesterase |
AGAP010915-RA |
2.72 |
2.89 |
3 |
|
COE13O |
AGAP011507-RA |
2.34 |
2.58 |
4 |
|
COE09895 - Putative Carboxylesterase |
AGAP010911-RA |
2.06 |
2.26 |
4 |
|
Glutathione-S-transferases |
|
|
|
|
|
GSTe4 |
AGAP009193-RA |
15.60 |
23.31 |
4 |
|
GSTd1-5 |
AGAP004164-RA |
2.24 |
2.29 |
4 |
| GSTd3 | AGAP004382-RA | 2.23 | 2.50 | 4 |
N° probes = number of significant probes for each gene on the microarray (maximum = 4).