Table 3.
MDDR2 structure activity classes
| Activity index | Activity class | Active molecules | Pair-wise similarity |
|---|---|---|---|
| 09249 |
Muscarinic (M1) agonists |
900 |
0.257 |
| 12455 |
NMDA receptor antagonists |
1400 |
0.311 |
| 12464 |
Nitric oxide synthase inhibitors |
505 |
0.237 |
| 31281 |
Dopamine-hydroxylase inhibitors |
106 |
0.324 |
| 43210 |
Aldose reductase inhibitors |
957 |
0.370 |
| 71522 |
Reverse transcriptase inhibitors |
700 |
0.311 |
| 75721 |
Aromatase inhibitors |
636 |
0.318 |
| 78331 |
Cyclooxygenase inhibitors |
636 |
0.382 |
| 78348 |
Phospholipase A2 inhibitors |
617 |
0.291 |
| 78351 | Lipoxygenase inhibitors | 2111 | 0.365 |