Table 2. Classification metrics of PCa for parenchymal tissues, evaluated by LRS only, AFLS only, and dMOD (unit: %).
| Classification method | PCa Type | Mode | Sensitivity | Specificity | Accuracy | AUC*100 |
|---|---|---|---|---|---|---|
| 3-tissue-type classification* | All high grade (GS≥7) | AFLS | 64.2 ± 2.5 | 69.2 ± 1.8 | 67.1 ± 0.7 | 72.9 ± 0.5 |
| LRS | 63.0 ± 1.5 | 82.9 ± 1.6 | 74.7 ± 1.0 | 80.4 ± 0.2 | ||
| dMOD | 79.0 ± 1.7 | 85.2 ± 1.1 | 82.7 ± 0.7 | 90.8 ± 0.4 | ||
| 5-tissue-type classification** | GS 9 | LRS | 84.4 ± 2.3 | 56.5 ± 0.7 | 59.4 ± 0.6 | 72.9 ± 0.5 |
| AFLS | 76.5 ± 3.2 | 75.9 ± 1.0 | 76.0 ± 0.9 | 85.4 ± 0.6 | ||
| dMOD | 82.3 ± 2.4 | 85.4 ± 0.7 | 85.1 ± 0.6 | 91.5 ± 0.7 | ||
| GS 8 | LRS | 71.8 ± 2.6 | 72.6 ± 1.8 | 72.5 ± 1.6 | 77.1 ± 0.7 | |
| AFLS | 76.3 ± 4.9 | 86.7 ± 0.8 | 86.0 ± 0.6 | 90.0 ± 0.6 | ||
| dMOD | 81.5 ± 3.4 | 90.8 ± 0.9 | 90.1 ± 0.8 | 93.6 ± 0.7 | ||
| GS 7 | LRS | 71.9 ± 2.2 | 82.7 ± 1.3 | 80.2 ± 0.7 | 87.9 ± 0.2 | |
| AFLS | 70.9 ± 2.0 | 72.4 ± 0.9 | 72.1 ± 0.7 | 78.6 ± 0.7 | ||
| dMOD | 86.0 ± 2.4 | 88.5 ± 0.7 | 87.9 ± 0.6 | 94.7 ± 0.4 |
* The values listed in this category implicate the classification for all high-grade PCa tissue group against non-cancer tissue types (nPZ and BPH). ** The values listed in this category implicate the classification for each PCa tissue group (e.g., GS 9) against remaining tissue groups. All are high grade (GS≥7).