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. 2014 May 5;2014:376191. doi: 10.1155/2014/376191

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Copyright © 2014 Akito Maeshima et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effects of follistatin on fibrotic changes in kidneys after UUO. (a) Histological changes in kidneys after UUO were assessed by PAS staining. (A, D) contralateral kidneys, 7 days. (B, E) saline-treated UUO kidneys, 7 days. (C, F) follistatin-treated UUO kidneys, 7 days. Magnification: ×100 (A–C), ×400. (b) Fibrotic changes in kidneys after UUO were assessed by Masson-trichrome staining. (A, C) saline-treated UUO kidneys, 7 days. (B, D) follistatin-treated UUO kidneys, 7 days. Magnification: ×100 (A, B), ×400 (C, D). (c) Semiquantitative analysis of fibrotic changes in UUO kidneys. Fibrotic score was measured as described in Section 2. Data are presented as mean ± SE (n = 5). Saline (white bars), follistatin (black bars). *P < 0.05 versus saline.