Table 1.
Description of the polymorphisms included in this study.
|
Gene symbols (HGNC) |
Gene name | Polymorphism (SNP) | Location | SNP ID | |
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 |
|
| |||||
| 1 | GPX1 | Glutathione peroxidase 1 | C>T (P198L) | exon 1 | rs1050450 |
| 2 | GPX2 | Glutathione peroxidase 2 (gastrointestinal) | G>A (R146C) | exon 2 | rs17880492 |
| 3 | GPX3 | Glutathione peroxidase 3 (plasma) | 249G>A | 3′ UTR | rs2070593 |
| 4 | GPX4 | Glutathione peroxidase 4 (phospholipid hydroperoxidase) | C718T | 3′ UTR | rs713041 |
| 5 | GSR | Glutathione reductase | T>C (30546636T>C) | intron 9 | rs2551715 |
| 6 | SOD2 | Superoxide dismutase 2, mitochondrial | A16V | exon 2 | rs4880 |
| 7 | SOD3 | Superoxide dismutase 3, extracellular | A40T (A58T) | exon 3 | rs2536512 |
| 8 | CAT | Catalase —//— |
−21A>T (−89A>T) | 5′ UTR | rs7943316 |
| 9 | CAT | −262C>T (4760C>T) | 5′ UTR | rs1001179 | |
| 10 | GCLM | Glutamate-cysteine ligase, modifier subunit | −588C>T (4704C>T) | 5′ UTR | rs41303970 |
| 11 | GCLM | −23G>T | 5′UTR | rs743119 | |
| 12 | NQO1 | NAD(P)H dehydrogenase, quinone 1 —//— |
P187S | exon 6 | rs1800566 |
| 13 | NQO1 | R139W | exon 4 | rs4986998 | |
| 14 | CYBA | Cytochrome b-245, alpha polypeptide —//— —//— |
242C>T (Y72H) | exon 4 | rs4673 |
| 15 | CYBA | 640A>G (24G>A) | 3′ UTR | rs1049255 | |
| 16 | CYBA | −930A>G | 5′ UTR | rs9932581 | |
| 17 | MPO | Myeloperoxidase | −463G>A (4535G>A) | 5′ UTR | rs2333227 |
| 18 | PRDX1 | Peroxiredoxin 1 | C>A | 5′ UTR | rs17522918 |
| 19 | TXNRD1 | Thioredoxin reductase 1 | C>G | 5′ UTR | rs1128446 |
| 20 | FMO3 | Flavin-containing monooxygenase 3 | E158K | exon 4 | rs2266782 |
| 21 | CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | I462V | exon 7 | rs1048943 |
| 22 | CYP1A1 | T6235C | 3′ UTR | rs4646903 | |
| 23 | CYP2E1 | Cytochrome P450, family 2, subfamily E, polypeptide 1 —//— —//— |
−1293G>C | 5′ UTR | rs3813867 |
| 24 | CYP2E1 | −1053C>T | 5′ UTR | rs2031920 | |
| 25 | CYP2E1 | 7632T>A | intron 6 | rs6413432 | |
| 26 | CYP2E1 | 9896C>G | intron 7 | rs2070676 | |
| 27 | EPHX1 | Epoxide hydrolase 1, microsomal (xenobiotic) | Y113H (337T>C) | exon 3 | rs1051740 |
| 28 | EPHX1 | H139R (416A>G) | exon 4 | rs2234922 | |
| 29 | PON1 | Paraoxonase 1 | Q192R | exon 6 | rs662 |
| 30 | PON2 | Paraoxonase 2 | C311S | exon 9 | rs7493 |
| 31 | GSTM1 | Glutathione S-transferase mu 1 | Expressor/deletion | exons 6-7 | — |
| 32 | GSTT1 | Glutathione S-transferase theta 1 | Expressor/deletion | exon 4 | — |
| 33 | GSTP1 | Glutathione S-transferase pi 1 —//— |
I105V | exon 5 | rs1695 |
| 34 | GSTP1 | A114V | exon 6 | rs1138272 | |
| 35 | TNF | Tumor necrosis factor | −308G>A | 5′ UTR | rs1800629 |
| 36 | IL1B | Interleukin 1, beta | −511C>T | 5′ UTR | rs16944 |
| 37 | IL3 | Interleukin 3 (colony-stimulating factor, multiple) | S27P | exon 1 | rs40401 |
| 38 | IL3 | −15C>T | 5′ UTR | rs31480 | |
| 39 | IL5 | Interleukin 5 (colony-stimulating factor, eosinophil) | C-703T | 5′ UTR | rs2069812 |
| 40 | CSF2RB (IL5RB) | Colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) | G1972A | exon 5 | rs131840 |
| 41 | IL9 | Interleukin 9 | T113M | exon 5 | rs2069885 |
| 42 | IL13 | Interleukin 13 | −1111C>T | 5′ UTR | rs1800925 |
| 43 | SCGB1A1 (CC16) | Secretoglobin, family 1A, member 1 (uteroglobin) | A38G | exon 1 | rs11549442 |
| 44 | SERPINA1 | Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | E288V | exon 3 | rs17580 |
| 45 | SERPINA1 | D365N | exon 5 | rs143370956 | |
| 46 | SERPINA1 | 1331G>A | 3′ UTR | rs11568814 | |