Table 2.
Allele frequencies of genes investigated in the present study.
| Gene | Polymorphism | Alleles | Allele frequency | |||
|---|---|---|---|---|---|---|
| Controls (n = 214) | Asthma, entire group (n = 215) |
Allergic asthma (n = 156) | Nonallergic asthma (n = 56) | |||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 |
|
| ||||||
| GPX2 | G>A (rs17880492) |
G | 0.991 | 0.981 | 0.987 | 0.964 |
| A | 0.009 | 0.019 | 0.013 | 0.036 | ||
| GPX3 | G>A (rs2070593) |
G | 0.703 | 0.726 | 0.734 | 0.696 |
| A | 0.297 | 0.274 | 0.266 | 0.304 | ||
| GPX4 | C718T (rs713041) |
718T | 0.402 | 0.391 | 0.407 | 0.348 |
| 718C | 0.598 | 0.609 | 0.593 | 0.652 | ||
| GSR | T>C (rs2551715) |
T | 0.442 | 0.398 | 0.362 | 0.491 |
| C | 0.558 | 0.602 | 0.638* | 0.509 | ||
| SOD2 | A16V (rs4880) |
16A | 0.528 | 0.486 | 0.481 | 0.509 |
| 16V | 0.472 | 0.514 | 0.519 | 0.491 | ||
| SOD3 | A40T (rs2536512) |
40A | 0.322 | 0.321 | 0.324 | 0.295 |
| 40T | 0.678 | 0.679 | 0.676 | 0.705 | ||
| PRDX1 | C>A (rs17522918) |
C | 0.923 | 0.937 | 0.942 | 0.920 |
| A | 0.077 | 0.063 | 0.058 | 0.080 | ||
| TXNRD1 | C>G (rs1128446) |
C | 0.808 | 0.821 | 0.808 | 0.857 |
| G | 0.192 | 0.179 | 0.192 | 0.143 | ||
| FMO3 | E158K (rs2266782) |
158E | 0.549 | 0.537 | 0.529 | 0.571 |
| 158K | 0.451 | 0.463 | 0.471 | 0.429 | ||
| TNF | −308G>A (rs1800629) |
−308G | 0.888 | 0.872 | 0.875 | 0.866 |
| −308A | 0.112 | 0.128 | 0.125 | 0.134 | ||
| IL1B | −511C>T (rs16944) |
−511C | 0.710 | 0.664 | 0.670 | 0.652 |
| −511T | 0.290 | 0.336 | 0.330 | 0.348 | ||
| IL3 | S27P (rs40401) |
27S | 0.738 | 0.685 | 0.686 | 0.688 |
| 27P | 0.262 | 0.315 | 0.314 | 0.313 | ||
| IL3 | −15C>T (rs31480) |
−15C | 0.741 | 0.683 | 0.686 | 0.688 |
| −15T | 0.259 | 0.317 | 0.314 | 0.313 | ||
| IL5 | C-703T (rs2069812) |
−703C | 0.673 | 0.778 | 0.788 | 0.732 |
| −703T | 0.327 | 0.222* | 0.212* | 0.268 | ||
| IL5RB (CSF2RB) | G1972A (rs131840) |
1972G | 0.831 | 0.866 | 0.872 | 0.848 |
| 1972A | 0.169 | 0.134 | 0.128 | 0.152 | ||
| IL9 | T113M (rs2069885) |
113T | 0.820 | 0.863 | 0.856 | 0.893 |
| 113M | 0.180 | 0.137 | 0.144 | 0.107 | ||
| IL13 | −1111C>T (rs1800925) |
−1111C | 0.729 | 0.693 | 0.692 | 0.714 |
| −1111T | 0.271 | 0.307 | 0.308 | 0.286 | ||
| CC16 (SCGB1A1) | A38G (rs11549442) |
38A | 0.347 | 0.367 | 0.372 | 0.366 |
| 38G | 0.653 | 0.633 | 0.628 | 0.634 | ||
| SERPINA1 | E288V (rs17580) |
288E | 0.993 | 0.991 | 0.990 | 0.991 |
| 288V | 0.007 | 0.009 | 0.010 | 0.009 | ||
| SERPINA1 | D365N (rs143370956) |
365D | 0.991 | 0.995 | 0.997 | 0.991 |
| 365N | 0.009 | 0.005 | 0.003 | 0.009 | ||
| SERPINA1 | 1331G>A (rs11568814) |
1331G | 0.937 | 0.933 | 0.926 | 0.946 |
| 1331A | 0.063 | 0.067 | 0.074 | 0.054 | ||
*Indicates a difference in minor allele frequency between asthmatics and controls.