Table 3.
Genotype frequencies of genes investigated in the present study.
| Gene | Polymorphism | Genotypes | Genotype distributions, n (%) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n = 214) | Asthma, entire group (n = 215) | Allergic asthma (n = 156) | Nonallergic asthma (n = 56) | |||||||
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 |
|
| ||||||||||
| GPX2 | G>A (rs17880492) |
GG | 210 | 98.1 | 207 | 96.3 | 152 | 97.4 | 52 | 92.9 |
| GA | 4 | 1.9 | 8 | 3.7 | 4 | 2.6 | 4 | 7.1 | ||
| AA | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||
| GPX3 | G>A (rs2070593) |
GG | 105 | 49.1 | 113 | 52.6 | 83 | 53.2 | 28 | 50.0 |
| GA | 91 | 42.5 | 86 | 40.0 | 63 | 40.4 | 22 | 39.3 | ||
| AA | 18 | 8.4 | 16 | 7.4 | 10 | 6.4 | 6 | 10.7 | ||
| GPX4 | C718T (rs713041) |
718TT | 31 | 14.5 | 33 | 15.3 | 25 | 16.0 | 8 | 14.3 |
| 718TC | 110 | 51.4 | 102 | 47.4 | 77 | 49.4 | 23 | 41.1 | ||
| 718CC | 73 | 34.1 | 80 | 37.2 | 54 | 34.6 | 25 | 44.6 | ||
| GSR | T>C (rs2551715) |
TT | 40 | 18.7 | 32 | 14.9 | 17 | 10.9* | 15 | 26.8 |
| TC | 109 | 50.9 | 107 | 49.8 | 79 | 50.6 | 25 | 44.6 | ||
| CC | 65 | 30.4 | 76 | 35.3 | 60 | 38.5 | 16 | 28.6 | ||
| SOD2 | A16V (rs4880) |
16AA | 59 | 27.6 | 49 | 22.8 | 34 | 21.8 | 15 | 26.8 |
| 16AV | 108 | 50.5 | 111 | 51.6 | 82 | 52.6 | 27 | 48.2 | ||
| 16VV | 47 | 22.0 | 55 | 25.6 | 40 | 25.6 | 14 | 25.0 | ||
| SOD3 | A40T (rs2536512) |
40AA | 21 | 9.8 | 24 | 11.2 | 19 | 12.2 | 4 | 7.1 |
| 40AT | 96 | 44.9 | 90 | 41.9 | 63 | 40.4 | 25 | 44.6 | ||
| 40TT | 97 | 45.3 | 101 | 47.0 | 74 | 47.4 | 27 | 48.2 | ||
| PRDX1 | C>A (rs17522918) |
CC | 182 | 85.0 | 188 | 87.4 | 138 | 88.5 | 47 | 83.9 |
| CA | 31 | 14.5 | 27 | 12.6 | 18 | 11.5 | 9 | 16.1 | ||
| AA | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||
| TXNRD1 | C>G (rs1128446) |
CC | 140 | 65.4 | 145 | 67.4 | 101 | 64.7 | 42 | 75.0 |
| CG | 66 | 30.8 | 63 | 29.3 | 50 | 32.1 | 12 | 21.4 | ||
| GG | 8 | 3.7 | 7 | 3.3 | 5 | 3.2 | 2 | 3.6 | ||
| FMO3 | E158K (rs2266782) |
158EE | 57 | 26.6 | 59 | 27.4 | 39 | 25.0 | 20 | 35.7 |
| 158EK | 121 | 56.5 | 113 | 52.6 | 87 | 55.8 | 24 | 42.9 | ||
| 158KK | 36 | 16.8 | 43 | 20.0 | 30 | 19.2 | 12 | 21.4 | ||
| TNF | −308G>A (rs1800629) |
−308GG | 170 | 79.4 | 162 | 75.4 | 118 | 75.6 | 42 | 75.0 |
| −308GA | 40 | 18.7 | 51 | 23.7 | 37 | 23.7 | 13 | 23.2 | ||
| −308AA | 4 | 1.9 | 2 | 0.9 | 1 | 0.6 | 1 | 1.8 | ||
| IL1B | −511C>T (rs16944) |
−511CC | 114 | 53.3 | 91 | 42.1 | 67 | 43.0* | 23 | 41.1 |
| −511CT | 76 | 35.5 | 105 | 48.6 | 75 | 48.1* | 27 | 48.2 | ||
| −511TT | 24 | 11.2 | 20 | 9.3 | 14 | 9.0 | 6 | 10.7 | ||
| IL3 | S27P (rs40401) |
27SS | 120 | 56.1 | 104 | 48.2 | 77 | 49.4 | 25 | 44.6 |
| 27SP | 76 | 35.5 | 88 | 40.7 | 60 | 38.5 | 27 | 48.2 | ||
| 273P | 18 | 8.4 | 24 | 11.1 | 19 | 12.2 | 4 | 7.1 | ||
| IL3 | −15C>T (rs31480) |
−15CC | 120 | 56.1 | 103 | 47.7 | 77 | 49.4 | 25 | 44.6 |
| −15CT | 77 | 36.0 | 89 | 41.2 | 60 | 38.5 | 27 | 48.2 | ||
| −15TT | 17 | 7.9 | 24 | 11.1 | 19 | 12.2 | 4 | 7.1 | ||
| IL5 | C-703T (rs2069812) |
−703CC | 90 | 42.1 | 132 | 61.1 | 97 | 62.2* | 31 | 55.4 |
| −703CT | 108 | 50.5 | 72 | 33.3 | 52 | 33.3* | 20 | 35.7* | ||
| −703TT | 16 | 7.5 | 12 | 5.6 | 7 | 4.5 | 5 | 8.9 | ||
|
IL5RB
(CSF2RB) |
G1972A (rs131840) |
1972GG | 136 | 67.7 | 160 | 74.1 | 118 | 75.6 | 39 | 69.6 |
| 1972GA | 62 | 30.9 | 54 | 25.0 | 36 | 23.1 | 17 | 30.4 | ||
| 1972AA | 3 | 1.5 | 2 | 0.9 | 2 | 1.3 | 0 | 0.0 | ||
| IL9 | T113M (rs2069885) |
113TT | 146 | 68.2 | 159 | 73.6 | 113 | 72.4 | 44 | 78.6 |
| 113TM | 59 | 27.6 | 55 | 25.5 | 41 | 26.3 | 12 | 21.4 | ||
| 113MM | 9 | 4.2 | 2 | 0.9 | 2 | 1.3 | 0 | 0.0 | ||
| IL13 | −1111C>T (rs1800925) |
−1111CC | 114 | 53.3 | 101 | 47.0 | 75 | 48.1 | 26 | 46.4 |
| −1111CT | 84 | 39.3 | 96 | 44.7 | 66 | 42.3 | 28 | 50.0 | ||
| −1111CT | 16 | 7.5 | 18 | 8.4 | 15 | 9.6 | 2 | 3.6 | ||
|
CC16
(SCGB1A1) |
A38G (rs11549442) |
38AA | 25 | 11.8 | 28 | 13.0 | 23 | 14.7 | 5 | 8.9 |
| 38AG | 97 | 45.8 | 102 | 47.4 | 70 | 44.9 | 31 | 55.4 | ||
| 38GG | 90 | 42.5 | 85 | 39.5 | 63 | 40.4 | 20 | 35.7 | ||
| SERPINA1 | E288V (rs17580) |
288EE | 211 | 98.6 | 212 | 98.1 | 153 | 98.1 | 55 | 98.2 |
| 288EV | 3 | 1.4 | 4 | 1.9 | 3 | 1.9 | 1 | 1.8 | ||
| 288VV | — | — | — | — | — | — | — | — | ||
| SERPINA1 | D365N (rs143370956) |
365DD | 210 | 98.1 | 214 | 99.1 | 153 | 98.1 | 55 | 98.2 |
| 365DN | 4 | 1.9 | 2 | 0.9 | 3 | 1.9 | 1 | 1.8 | ||
| 365NN | — | — | — | — | — | — | — | — | ||
| SERPINA1 | 1331G>A (rs11568814) |
1331GG | 188 | 87.9 | 187 | 86.6 | 133 | 85.3 | 50 | 89.3 |
| 1331GA | 25 | 11.7 | 29 | 13.4 | 23 | 14.7 | 6 | 10.7 | ||
| 1331AA | 1 | 0.5 | 0 | 0.0 | 0 | 0.0 | 0 | 0.0 | ||
*Indicates a difference in genotype frequency between asthmatics and controls.