Table 4.
A summary of best 2-, 3-, and 4-locus models of gene-gene interactions obtained by MDR analysis in allergic and nonallergic asthma (exhaustive search algorithm).
| Number of loci | Best n-locus (2-, 3-, and 4-locus) models of gene-gene interactions | Cross-validation consistency, % | Prediction error, % |
|---|---|---|---|
| Allergic asthma (men) | |||
| 2 | CYP2E1 9896C>G × IL5 C-703T | 40 | 52.5 |
| 3 | CAT −21A>T × IL5 C-703T × GSR T/C* | 50 | 50.3 |
| 4 | CAT −21A>T × GPX1 P198L × PON2 S311C × IL3 S27P | 30 | 53.6 |
|
| |||
| Allergic asthma (women) | |||
| 2 | EPHX1 Y113H × IL5 C-703T | 50 | 45.8 |
| 3 | EPHX1 Y113H × IL5 C-703T × GPX1 P198L** | 50 | 40.9 |
| 4 | EPHX1 Y113H × CYBA 640A>G × GPX4 C718T × PON2 S311C | 20 | 50.1 |
|
| |||
| Nonallergic asthma (men) | |||
| 2 | GPX3 G/A × GCLM −588C>T | 30 | 52.3 |
| 3 | GCLM −588C>T × GSR T/C × CYBA 242C>T | 20 | 57.0 |
| 4 | GPX3 G/A × FMO3 E158K × GPX1 P198L × CYBA −930A>G* | 30 | 49.2 |
|
| |||
| Nonallergic asthma (women) | |||
| 2 | EPHX1 Y113H × IL3 S27P | 30 | 46.7 |
| 3 | EPHX1 Y113H × GSR T/C × SOD2 A16V | 60 | 45.5 |
| 4 | EPHX1 Y113H × GSR T/C × SOD2 A16V × CYBA 640A>G* | 90 | 27.4 |
*Indicates best n-locus model of gene-gene interactions evaluated through 1000 permutation tests.
**A statistically significant (P value 0.001) model of gene-gene interactions.