Table 6.
Associations of genotype combinations with risk of nonallergic asthma (stratified by gender).
| Combinations of genotypes | Nonallergic asthma | Controls | Chi-square (P value1) | OR (95% CI) | ||
|---|---|---|---|---|---|---|
| N | % | N | % | |||
| Men | ||||||
| GPX1 198PL × CAT −21AA | 6 | 20.7 | 2 | 1.9 | 11.13 (0.001)* | 11.45 (2.49–52.66) |
| GPX1 198LL × GCLM −588CT | 4 | 13.8 | 3 | 2.9 | 3.50 (0.05) | 5.17 (1.20–22.31) |
| GPX3 GA × FMO3 158KK | 5 | 17.2 | 4 | 3.8 | 4.58 (0.03) | 5.06 (1.37–18.99) |
| GPX3 GA × GSR TT | 6 | 20.7 | 5 | 4.8 | 5.68 (0.02) | 5.05 (1.49–17.14) |
| GPX3 GA × CAT −21AA | 5 | 17.2 | 4 | 3.8 | 4.58 (0.03) | 5.06 (1.35–18.99) |
| GPX3 GG × GCLM −588CT | 11 | 37.9 | 15 | 14.3 | 8.12 (0.004) | 3.67 (1.47–9.28) |
| GSR TT × GCLM −588CT | 8 | 27.6 | 3 | 2.9 | 15.31 (0.0001)* | 11.58 (3.07–43.72) |
| GSR TT × FMO3 158KK | 4 | 13.8 | 1 | 1.0 | 7.16 (0.01) | 12.29 (1.84–82.03) |
| CAT −21AA × CYBA −930GG | 5 | 17.2 | 1 | 1.0 | 10.55 (0.001)* | 15.64 (2.44–100.3) |
| CAT −21AA × FMO3 158EE | 4 | 13.8 | 1 | 1.0 | 7.16 (0.01) | 12.29 (1.84–82.03) |
| GCLM −588CT × CYBA −930GG | 12 | 41.4 | 10 | 9.5 | 16.8 (0.00004)* | 6.71 (2.5–17.96) |
| CYBA −930GG × FMO3 158EE | 7 | 24.1 | 5 | 4.8 | 8.22 (0.004) | 6.09 (1.85–20.05) |
|
| ||||||
| Women | ||||||
| GPX1 198PL × GPX2 GA | 2 | 7.4 | 0 | 0.0 | 3.88 (0.05) | 21.47 (1.00–461.1) |
| GPX2 GG × IL5 −703CT | 6 | 22.2 | 56 | 51.4 | 6.29 (0.01) | 0.29 (0.11–0.74) |
| GPX2 GA × IL5 −703CC | 2 | 7.4 | 0 | 0.0 | 3.88 (0.05) | 21.5 (1.00–461.2) |
| EPHX1 113YH × IL5 −703CT | 1 | 3.7 | 24 | 22.0 | 3.69 (0.05) | 0.20 (0.04–1.09) |
| EPHX1 113HH × IL5 −703CC | 7 | 25.9 | 4 | 3.7 | 11.58 (0.001)* | 8.58 (2.43–30.26) |
1Means unadjusted P value. P value adjusted for multiple tests (P adj) is less than 0.002 in men and 0.004 in women. *A statistically significant association.