Table 4.
Pancreatic cancer cell line ABCB1 mRNA expression, haplotype, and sensitivity to gemcitabine.
| Cell line | ABCB1 expression | ABCB1 haplotype | GEM IC50 (μM) |
|---|---|---|---|
| AsPC-1 | 24.67 | 2677GG-3435CC | 25.59 |
| SU86.86 | 0.34 | 2677GG-3435CC | >100 |
| PL-45 | 0.98 | 2677GG-3435CT | 18.75 |
| PANC-1 | 1 | 2677GT-3435TT | >100 |
| BXPC-3 | 15.82 | 2677TT-3435TT | 0.11 |
| MiaPaca-2 | 0.75 | 2677TT-3435TT | 1.90 |
| CFPAC-1 | 1015.7 | 2677TT-3134TT | 1.09 |
GEM: gemcitabine. The expression of ABCB1 gene is normalized to PMM1 and showed as x-fold relative to the expression in PANC-1 cells.