Table 1.

Criteria for histopathologic evaluation.

Criteria	Score
Increase in submucosal collagen
None	0
Mild (submucosal collagen at least twice the thickness of the muscularis mucosa)	1
Marked (submucosal collagen more than twice the thickness of the muscularis mucosa)	2
Damage to muscularis mucosa
None	0
Present	1
Damage and collagen deposition in the muscularis propria
None	0
Mild (collagen deposition around the smooth muscle fibers)	1
Marked (same as mild, with collagen deposition replacing some of the fibers)	2