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. Author manuscript; available in PMC: 2014 Nov 14.
Published in final edited form as: J Med Chem. 2013 Oct 28;56(21):8765–8780. doi: 10.1021/jm401232v

Figure 4.

Figure 4

18a modeled in place of primer 3’-terminal AZTMP in the N- and P-sites of HIV RT. (A) Conformational flexibility of the furanose C3’ triazole-naphthalene ring substituents of 18a; (B) Primer 3’-terminal 18a in the N-site may sterically conflict with Gln151 and Arg72, but this conflict can be resolved by rotation of the triazole-naphthalene substituent; (C) No steric conflicts noted for primer 3’-terminal 18a in the P-site; (D) The triazole-naphthalene substituent of primer 3’-terminal 18a in the P-site partially occupies the N-site.