. Author manuscript; available in PMC: 2014 Nov 14.

Published in final edited form as: J Med Chem. 2013 Oct 28;56(21):8765–8780. doi: 10.1021/jm401232v

Table 4.

EC₅₀ (μM) values for AZT and AZT-triazole derivative 18a against wild type (WT), AZT-resistant (AZTr), and NNRTI-resistant (NNRTIr) HIVs.

Compound	WT HIV	AZTr HIV	NNRTIr HIV^a
AZT	0.14	7.9 (56)^b	0.12 (1)
18a	1.0	9.1 (9)	0.6 (0.6)

NNRTIr HIV possesses L100I/K103N mutations in RT that confer high-level resistance to most NNRTIs;

Fold resistance relative to WT HIV.