Skip to main content
. 2012 Dec 2;4(1):113–117. doi: 10.1021/ml300335r

Table 2. Imidazopyridine SAR, Antiviral, and FASN Inhibitory Activities.

graphic file with name ml-2012-00335r_0005.jpg

graphic file with name ml-2012-00335r_0006.jpg

a

Biochemical inhibition of human FASN.

b

Biochemical inhibition of rat FASN.

c

Inhibition of HCV RNA in the replicon system, typically determined only for more active compounds. See the Supporting Information for correlations across a larger number of analogues. Telaprevir was used as a positive control.

d

Inhibition of cell viability.

e

SI = EC50/CC50; n ≥ 2, and CV ≤ 50%.