Table 3. In Vitro and in Vivo Inhibition of de Novo Palmitate Synthesis by Compound 19.

human IC50 (HeLa, μM)	rat IC50 (NMU, μM)
in vitro
0.012	0.062

rat no.	[19]liverb (μM)	% inhibitionc
in vivo: 15 mg/kga
1	1.7	33
2	0.16	2
3	0.13	9
4	2.9	35
5	8.1	70
in vivo: 50 mg/kga
1	23.6	91
2	14.4	96
3	12.6	52
4	9.8	100
5	3.4	40

^aOral dose.

^bLiver level of 19 at 8 h.

^c% inhibition of de novo palmitate synthesis at 8 h as compared to vehicle group.