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. 2013 May 28;4(7):671–674. doi: 10.1021/ml400098w

Scheme 2. Preparation of A-Ring Precursors 2cf from Enyne Alcohol 10.

Scheme 2

Reagents and conditions: (a) DIAD, PPh3, 1,2,4-triazole, THF, 94%. (b) DIAD, PPh3, 1H-1,2,3-triazole, THF, 2d 85% and 2e 15%. (c) MsCl, Et3N, CH2Cl2, 91%. (d) NaH, imidazole, THF, 71%.