Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Mar 12;42(9):5644–5656. doi: 10.1093/nar/gku190

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Figure 3. — The DNA damage checkpoint promotes HR and suppresses break-induced LOH. (A) Percentage DSB-induced marker loss of Ch¹⁶-RMGAH in wild-type (TH2130), rad26Δ (TH3410), crb2Δ (TH3383) and OPcdc25 (TH3395) backgrounds. (B) The DNA replication checkpoint does not suppress break-induced LOH. Percentage DSB-induced marker loss of Ch¹⁶-RMGAH in wild-type (TH2130), mrc1Δ (TH3253) and cds1Δ (TH3256) backgrounds. (C) An additional role for Chk1 activation in promoting HR and suppressing break-induced LOH. Percentage DSB-induced marker loss of Ch¹⁶-YAMGH in wild-type (TH3317), chk1Δ (TH3153), rad9-T412A (TH5381), rad4.110 (TH4481) and rad3Δchk1Δ (TH3623) backgrounds. For (A), (B) and (C) the levels of NHEJ/SCC, GC, Ch¹⁶ loss and extensive LOH are shown. Data are the mean of three experiments and standard errors of the mean are indicated. The asterisk (*) represents P < 0.05 compared to wild-type.