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. 2014 Mar 12;42(9):5671–5688. doi: 10.1093/nar/gku200

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© Published by Oxford University Press Nucleic Acids Research 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

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Figure 2. — RECQL1 actively unwinds both damaged and undamaged telomeric D-loops. (A) A representative gel showing RECQL1 helicase activity on both telomeric (DL1) and non-telomeric (DLmix) D-loops. (B) Plot showing unwinding efficiency of RECQL1 on both DL1 and DLmix. (C) Representative gels showing RECQL1 helicase activity on telomeric D-loops containing 8-oxoguanine located toward either 3′-end (DL2), 5′-end (DL3) or both the ends (DL4) of the invading strand and thymine glycol located toward either 3′-end (DL5) or 5′-end (DL6) of the invading strand. (D) Plot comparing the unwinding efficiency of RECQL1 on both undamaged and damaged telomeric D-loops (DL1-DL6). (E) Schematic representation of both undamaged (DL1) and damaged telomeric D-loops (DL2–DL6) containing either an 8-oxoguanine (8) or a thymine glycol (Tg) located toward 5′- or 3′- end of the invading strand. The asterisk represents the γP³² ATP labeling at 5′-end of the invading strand.