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Loss of RECQL1 leads to telomere sister-chromatid exchanges (T-SCEs). (A) Helicase activity of RECQL1 (2–100 nM) on static telomeric HJ substrate. (B) Co-FISH analysis was performed on RECQL1 KD cells (U2OS) and representative images of the metaphase spreads of RECQL1 KD and scrambled cells showing the T-SCE events shown in white asterisks. (C) Plot showing % T-SCEs in scrambled and RECQL1 KD cells. Representative images of a single chromosome showing T-SCEs were shown in the inset.
