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. 2014 Mar 7;42(9):e76. doi: 10.1093/nar/gku182

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© The Author(s) 2014. Published by Oxford University Press [on behalf of Nucleic Acids Research].

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Paired sample test on matched tumor and normal in BRCA and THCA. (A and B) Volcano plots illustrate the significant interactions with −log 10(FDR) as a function of the averaged ProMISe log2 fold-change in BRCA and THCA tumors, respectively. (C and D) Three-way Venn diagram showing the overlaps among genes with differential expression (blue), genes with differential interactions (red), and putative cancer gene hubs (green) (21), respectively. Hypergeometric p-values are displayed near each pairwise overlap, and the common genes are displayed near the overlap.