Table 1. Antiplasmodial Activity, Resistance Indices, β-Hematin Inhibition, and Cytotoxicity Data for the Hybrids^a.

^aSE ≤ 7%, n = 3

^bIC₅₀ (μM) antiplasmodial activity against P. falciparum.

^cIC₅₀ represent the molar equivalents of test compound relative to β-hematin required to inhibit β-hematin formation by 50%; A = controls; B = benzylated analogues, C = deprotected analogues, D = methoxy analogues, and ND = not determined.