Table 4. In Vitro Antibacterial Activity of Compounds 20–23 Bearing a [1,2,3]Triazole C-5 Side Chain on the Oxazolidinone Ring.
minimum inhibitory concentration (μg/mL) |
||||||||||
---|---|---|---|---|---|---|---|---|---|---|
compd | S.a.a | S.a.b | S.a.c | S.a.d | E.f.e | E.f.f | M.c.g | S.p.h | S.p.i | H.i.j |
1 | 2 | 2 | 2 | 32 | 4 | 2 | 8 | 1 | 0.5 | 16 |
20 | 0.25 | 0.5 | 0.25 | 4 | 0.5 | 0. 5 | 4 | ≤0.063 | ≤0.063 | 4 |
21 | 0.125 | 0.25 | 0.125 | 2 | 0.25 | 0.25 | 2 | ≤0.063 | ≤0.063 | 2 |
22 | 0.25 | 0.5 | 0.25 | 8 | 0.5 | 0.25 | 8 | ≤0.063 | ≤0.063 | 4 |
23 | 0.125 | 0.25 | 0.25 | 2 | 0.25 | 0.25 | 4 | ≤0.063 | ≤0.063 | 2 |
Staphylococcus aureus SR20549.
Staphylococcus aureus Smith.
Staphylococcus aureus SR3637 (methicillin-resistant).
Staphylococcus aureus NRS271(linezolid-resistant).
Enterococcus faecalis SR1004.
Enterococcus faecium SR7940 (vancomycin-resistant).
Moraxella catarrhalis SR26840.
Streptococcus pneumonoiae SR26207.
Streptococcus pneumonoiae SR11031 (penicillin-resistant).
Haemophilus influenzae SR27914.