Table 5. In Vivo Therapeutic Effects of Selected Oxazolidinone Analogues in a Mouse Lethal Systemic Infection Model Employing S. aureus SR3637.
| therapeutic effect ED50 (mg/kg)a |
|||
|---|---|---|---|
| administration route |
|||
| compd | MIC (μg/mL) | iv | po |
| 13 | 0.25 | >10 (1: 1.98) | N.T. |
| 14 | 0.5 | 3.05 (1: 4.32) | N.T. |
| 15 | 0.5 | 3.17 (1: 2.46) | 3.05 (1: 2.83) |
| 16 | 0.25 | 1.09 (1: 1.73) | 1.05 (1: 2.83) |
| 18 | 0.25 | 0.34 (1: 2.13) | 0.55 (1: 1.98) |
| 21 | 0.125 | 0.95 (1: 1.73) | 1.02 (1: 2.83) |
| 23 | 0.25 | N.T. | 0.95 (1: 3.87) |
a
Compound 1 was used as reference in each test, and its ED50 value was shown in the parentheses. N.T.: not tested.