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| CYP450 isoform, IC50 (μM) |
MAO inhibition (%) (30 μM
of each compound) |
|||||
|---|---|---|---|---|---|---|
| compd | 1A2 | 2C9 | 2D6 | 3A4 | A | B |
| 1 | >20 | >20 | >20 | >20 | 61.3 | 70.4 |
| 16 | >20 | >20 | >20 | >20 | 54.8 | 52.8 |
| 18 | >20 | >20 | >20 | >20 | 55.9 | 78.2 |
| 21 | >20 | >20 | >20 | 15 | 41.2 | 26.7 |
| 23 | >20 | >20 | >20 | >20 | 33.2 | 27.9 |
