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Kinome-wide selectivity profile of 7b. Red spheres highlight kinases for which the residual activity remaining after treatment with the inhibitor at a concentration of 0.1 μM/L was less than 45% of DMSO control using a competition binding assay that measures the ability of a compound to compete with an immobilized, active-site directed ligand (KINOMEscan, Discoverx, Inc., San Diego, CA).18
