Skip to main content
. 2013 May 31;4(8):742–746. doi: 10.1021/ml400146c

Table 1. Enzyme and Cell Data for Compounds 1–6.

graphic file with name ml-2013-00146c_0005.jpg

  NRR′ HER2 enz IC50a cl.24 IC50 (p-HER2)a
1 NH2 0.046 0.107
2 NHMe 0.014 0.060
3 NHEt 0.033 0.12
4 NHCH2CH2OMe 0.091 0.25
5 NHiPr 0.11 0.41
6 NMe2 0.22 0.67
a

μM; n = 2 or more; CIR values available in the Supporting Information.