Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
| no. | R1 (2° amine) | Kdis (μM) |
|---|---|---|
| 2 | 1-methylpiperazine | 6.9 ± 1.5 |
| 4 | F | >20 |
| 5 | 1,2-dimethylpiperazine | 4.7 ± 0.8 |
| 6 | 1-methyl-1,4-diazepane | 7.0 ± 1.1 |
| 7 | morpholine | >20 |
| 8 | piperidine | >20 |
| 9 | 1-ethylpiperazine | >20 |
| 10 | N1,1-dimethylpyrrolidin-3-amine | 15.8 ± 2.0 |
| 11 | N1,1-dimethylpiperidin-4-amine | >20 |
| 13 | piperazine | >20 |
| 15 | pyrrolidin-3-amine | >20 |
| 17 | piperidin-4-amine | >20 |
| 18 | N1,1,2-trimethylethane-1,2-diamine | >20 |
