Table 3. Modifications of the Nitro Group at C-5.
| no. | R1 | Kdis (μM) |
|---|---|---|
| 2 | NO2 | 6.9 ± 1.5 |
| 62 | CO2Me | 6.6 ± 1.1 |
| 63 | CF3 | >10 |
| 64 | Br | >10 |
| 65 | NH2 | >10 |
| 66 | CO2H | >10 |
| 67 | cyclopropyl | >10 |
| 68 | 2-furanyl | 3.5 ± 0.3 |
| 69 | 4-pyridyl | 2.2 ± 0.1 |
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