Table 3. Selected PK Profile of Compounds 9a, 16a, and HSD-621.

		iva				poa
compd	species	Cl (mL/min/kg)	Vss (L/kg)	AUC (h ng/mL)	t1/2 (h)	Cmax (ng/mL)	tmax (h)	AUC (h ng/mL)	t1/2 (h)	F (%)
9a	mouseb	9.0	5.8	3588	9.5	449	0.5	3403	6.0	19
16a	mouseb	5.4	1.8	6131	4.2	1554	2.0	14005	2.8	46
HSD-621	mouseb	9.0	4.2	3600	6.1	987	2.0	11700	4.8	67
HSD-621	ratc	8.0	3.8	4310	8.6	656	1.8	6542	3.3	61
HSD-621	dogd	1.0	1.8	32358	20.3	1444	2.8	43488	17.2	54

^aSee the Experimental Procedures for dosing and analytical protocols.

^bC57B6 mice: iv dosed at 2 mg/kg in 50% DMSO/50% PEG200 and po dosed at 10 mg/kg in 2% Tween/0.5% methyl cellulose in water.

^cSD rat: iv dosed at 2 mg/kg in 50% DMSO/50% PEG200 and po dosed at 10 mg/kg in 2% Tween/0.5% methyl cellulose in water.

^dMale dog: iv dosed at 2 mg/kg in 50% DMSO/50% PEG200 and po dosed at 5 mg/kg in 2% Tween/0.5% methyl cellulose in water.