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. 2013 Aug 12;4(10):948–952. doi: 10.1021/ml400206q

Table 2. Representative SAR and Benzothiazole Ring System.

graphic file with name ml-2013-00206q_0006.jpg

compd R1 R2 X Itk pKi Lck pKi AurB pKi
8 Me Me C <5a <4.6 4.7
9 H H C 9.0 6.5 6.4
10 Me H C 9.4 6.6 6.5
11 Cl H C 9.5 7.1 6.6
12 CF3 H C 7.9a 7.3 6.6
13 Et H C 9.2 7.0 6.4
14 CN H C 9.6 7.2 7.1
15 OMe H N 9.7 7.1 6.5
16 H H N 9.6 7.0 7.0
17 Et H N 8.8 7.0 7.2
a

pKi measured at low ATP concentration.21