Table 2. Pharmacokinetic Parameters for 9na.
route | AUC(0–24 h) (μM·min) | t1/2 (min) | tmax (min) | Cmax (μM) | F% |
---|---|---|---|---|---|
i.v. | 25.4 | 762 | 2 | 0.29 | |
p.o. | 133 | 548 | 45 | 0.36 | 26.1 |
The pharmacokinetic parameters are obtained after a single i.v. (3 mg/kg) or oral (10 mg/kg) administration. The data are obtained from 12 mice in each treatment group.