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X-ray crystal structure of the Mnk2-KD (PDB entry 2AC3) and its homology model, in which the missing activation loop (purple, residues 232–250) and insertion I3 (blue, residues 304–310) were built. The homology model is generated using the crystal structure as a template, followed by multiple-threading alignments with I-TASSER (Table S1, Supporting Information). On the basis of the homology model, other Mnk2 mutant models were generated by Modeler.
