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. 2013 Apr 10;4(6):504–508. doi: 10.1021/ml300471d

Table 3. SAR Elements Evidenced for Positions 1, 3, and 6 of the Dehydropyrimidinyl Moiety.

graphic file with name ml-2012-00471d_0005.jpg

entry compd R1 R3 R6 EC50 (μM) Emax (% 7DC)
1 14 Me H Me >19b 29
2 15 H Me Me >30a 19
3 16 H H Et >30a >45b
a

Not calculated (no plateau).

b

Not determined (no plateau).