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. 2013 May 22;4(7):637–641. doi: 10.1021/ml400164t

Scheme 1. Synthetic Protocol Towards Target Hybrids 7a and 7b.

Scheme 1

Reagents and conditions: (i) MeOH, NaBH4, 0–5 °C, 2 h; (ii) pyridine, Ac2O, N2, 0 °C, 1 h; 20–25 °C, 24 h; (iii) DCM, DIC, HOBt, DMAP, 0 °C, 0.5 h; 20–25 °C, 12 h.